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Ulodesine (BCX4208) long-term safety when added to allopurinol in the chronic management of gout: A Phase 2 24-Week Blinded Safety Extension and Vaccine Challenge Study [abstract]

Second Generation The second generation moved from single GLP-1 activity toward dual incretin agonism

Intranasal administration of Ex-4 at a dose of 0.5 g/kg daily for 7 days before MCAO in mice, rather than intraperitoneal administration at an equivalent dose, exerted neuroprotective effect by reducing infarct volume and neurological deficits which were blocked by knocking down GLP-1 receptor with shRNA (97)

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